Erythropoietin in traumatic brain injury: The "golden bullet" on the horizon?
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Erythropoietin in traumatic brain injury: the "golden bullet" on the horizon?
The study by Liao and colleagues investigated the cellular and molecular events of erythropoietin (EPO)-mediated neuroprotection in traumatic brain injury (TBI).[1] Using the “classic” Feeney cortical contusion model, the authors performed an experimental study on 130 Wistar rats, designed to elucidate in more detail the established antiapoptotic effects of recombinant human EPO (rhEPO). Animal...
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Objective(s) Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations ...
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ژورنال
عنوان ژورنال: Neurology India
سال: 2009
ISSN: 0028-3886
DOI: 10.4103/0028-3886.59461